NAD+ precursor. Raises blood NAD+ in human RCTs (Yi et al., GeroScience 2023; Yoshino et al., Science 2021); functional longevity outcomes still under study. Huberman Lab #70 — promising, not proven.
Fascia hydration, nervous-system downshift, deeper sleep architecture.
D3 for bone and endocrine support; K2 directs calcium away from soft tissue.
Cell-membrane fluidity, collagen synthesis, cognitive and fascial resilience.
Amino acid load for fibroblasts — joint, skin, fascial integrity over time.
Reduced form — directly usable by mitochondria. Essential over 40.
Adjunct — PGC-1α activation shown in cell/rodent models (Chowanadisai et al., J Biol Chem 2010); human evidence preliminary. Comfort tier, not a primary mitochondrial recommendation.
Deep-amber lenses block the 480nm melanopsin peak that suppresses melatonin (Hattar et al., Science 2002). Light intensity reduction is the primary lever; glasses are secondary. Subtle-yellow / clear tints do not pass the bar.
Medical disclaimer. Supplements are not a substitute for medical care. If you have a diagnosed condition or are on prescription medication, consult your clinician before adding any product to your daily routine.